New version of Tenofovir

Tenofovir disoproxil fumarate (TDF) is one of the most widely used antiretroviral drugs. It is highly effective in treating HIV,and for most people, generally safe and well-tolerated. However, in a small minority of cases it can cause kidney problems. And TDF has an impact on bones…for most people, this is small and not noticeable, but […]

New form of tenofovir has good results for people aged 50+

One of the most widely used anti-HIV drugs is tenofovir disoproxil fumarate (TDF) – it is included in the tablets Viread, Truvada, Atripla, Eviplera and Stribild. TDF is highly effective and generally safe and well-tolerated, but can cause kidney and bone problems for some people. Tenofovir alafenamide (TAF) is a new form of the drug that is delivered more efficiently to […]

Triumeq – A New Single-tablet HIV Regimen

The U.S. Food and Drug Administration (FDA) has approved Triumeq, ViiV Healthcare’s single-tablet, triple-combination antiretroviral (ARV) regimen, as a first-line therapy to treat HIV. The tablet is comprised of the integrate inhibitor (II) Tivicay (dolutegravir) plus Epzicom (abacavir and lamivudine) and is the first single-tablet regimen to receive approval that does not contain Truvada (tenofovir/emtricitabine). […]

HIV, Hepatitis C and Bone Problems

We already know that – compared to the general population –osteoporosis (problems due to weak bones) is more common both among people living with HIV and among people living with hepatitis C (HCV). There is a link between the viruses and bone loss, possibly caused by the immune system’s ongoing inflammation and activation, as it attempts to […]

HIV and Kidney Disease

Kidney disease can be an important cause of serious illness in people living with HIV. Possible causes include risk factors such as high blood pressure and diabetes; the damage caused by untreated HIV infection; and the side-effects of some anti-HIV drugs. Researchers have looked at the impact of starting HIV treatment on the risk of kidney disease. They monitored kidney […]

Kidney Disease and Tenofovir

Tenofovir is a widely-used anti-retroviral drug used in the treatment of HIV. It is very effective, and doesn’t cause the severe side-effects seen with some of the older HIV drugs. Anecdotally, there has been a long-standing concern that in a small minority of patients, tenofovir can lead to some problems with kidney function. Up till […]

Microbicide Trial Halted

A microbicide is a topical agent that, when applied to a mucosal surface, serves as a barrier to infection. Microbicides can come in the form of a gel, cream, foam, or ring. There is a lot of work being done to see if a microbicides can be developed that protects against HIV, from either vaginal or […]