Generic HIV Drugs

The financial pressures faced by HIV clinics in the NHS was a major theme of the recent British HIV Association conference. Doctors discussed how they can keep costs down without compromising the quality of care. One of the most important ways they can do so is to switch some patients from branded, expensive drugs to […]

Long-lasting injectable formulation?

An oral combination therapy of two antiretroviral drugs, the non-nucleoside rilpivirine (Edurant, also inEviplera/Complera) and the new integrase inhibitor GSK1265744 (744), was at least as effective as a standard nucleosides-plus-efavirenz triple combination in keeping viral load undetectable in people taking it. This dual combination was a maintenance therapy, meaning that patients did not start on it […]

HIV Mechanism

HIV replicates by infecting activated CD4 T cells, which then produce copies of the virus and eventually die of programmed cell death, or apoptosis. But if that were all, these destroyed T cells could easily be replaced by resting  T cells cells, which make up 95% of the targets encountered by the invading virus. Instead, […]

Generic HIV Drugs

In the next few years, some of the most widely-used HIV drugs will come off patent in the UK. This article asks: what are the implications for the tablets we take – and for our health? From next year in the UK, your anti-HIV drugs may start to look different. One pill may be replaced by two or […]

New “Quad” Pills Safe and Effective

A new study has shown that the ‘Quad’ single-tablet regimen has antiviral efficacy at least as good as comparison regimens and is associated with fewer adverse events than Atripla or ritonavir-boosted atazanavir (Reyataz). The new four-in-one ‘Quad’ coformulation contains the next-generation integrase inhibitor elvitegravir, the novel boosting agent cobicistat, and tenofovir and FTC (the latter two are […]

New Once-a-Day Drugs Get Approval

In recent years, HIV drugs have been combined, to make them easier to take by reducing the number of pills that need to be swallowed. Perhaps the most well-know example of this is Atripla, a one pill, once-a-day HIV treatment containing efavirenz, emtricitabine, and tenofovir. Efavirenz is a type of medicine called a non-nucleoside reverse transcriptase […]