New version of Tenofovir

Tenofovir disoproxil fumarate (TDF) is one of the most widely used antiretroviral drugs. It is highly effective in treating HIV,and for most people, generally safe and well-tolerated. However, in a small minority of cases it can cause kidney problems. And TDF has an impact on bones…for most people, this is small and not noticeable, but […]

New form of tenofovir has good results for people aged 50+

One of the most widely used anti-HIV drugs is tenofovir disoproxil fumarate (TDF) – it is included in the tablets Viread, Truvada, Atripla, Eviplera and Stribild. TDF is highly effective and generally safe and well-tolerated, but can cause kidney and bone problems for some people. Tenofovir alafenamide (TAF) is a new form of the drug that is delivered more efficiently to […]

Triumeq – A New Single-tablet HIV Regimen

The U.S. Food and Drug Administration (FDA) has approved Triumeq, ViiV Healthcare’s single-tablet, triple-combination antiretroviral (ARV) regimen, as a first-line therapy to treat HIV. The tablet is comprised of the integrate inhibitor (II) Tivicay (dolutegravir) plus Epzicom (abacavir and lamivudine) and is the first single-tablet regimen to receive approval that does not contain Truvada (tenofovir/emtricitabine). […]

HIV, Age and the Kidneys

It is well known that kidney function declines with age. An increased risk of kidney (renal) failure for people with HIV has been associated with a low CD4 cell count, a high viral load and treatment with some antiretroviral drugs. Researchers in London examined data from over 15,000 HIV-positive patients. As expected, kidney function declined with age, but it was always […]

Kidney Stones and Atazanavir

Overall, HIV treatment reduces the risk of kidney disease. However, some anti-HIV drugs can affect kidney function and others can cause kidney stones. Atazanavir (taken with ritonavir as a “booster”) is a powerful anti-HIV drug in the class called protease inhibitors (PIs), and typically causes only mild side-effects. A new study suggests that treatment with ritonavir-boosted atazanavir is associated with a […]

HIV and Kidney Disease

Kidney disease can be an important cause of serious illness in people living with HIV. Possible causes include risk factors such as high blood pressure and diabetes; the damage caused by untreated HIV infection; and the side-effects of some anti-HIV drugs. Researchers have looked at the impact of starting HIV treatment on the risk of kidney disease. They monitored kidney […]

Diabetes increases risk of chronic kidney disease

Kidney disease is an increasingly important cause of serious illness and death in people with HIV. Doctors looked at the medical records of over 30,000 people and compared their risk of kidney disease according to whether they had HIV, diabetes, or both. People without either HIV or diabetes had the lowest risk of kidney disease and those […]

Kidney Disease and Tenofovir

Tenofovir is a widely-used anti-retroviral drug used in the treatment of HIV. It is very effective, and doesn’t cause the severe side-effects seen with some of the older HIV drugs. Anecdotally, there has been a long-standing concern that in a small minority of patients, tenofovir can lead to some problems with kidney function. Up till […]