Switching from Efavirenz Does Not Improve Cognitive Function

Despite effective antiretroviral therapy (ART), mild cognitive impairment (things like decreased attention span, poorer memory, worse problem-solving ability) remains common in people living with HIV. The reasons for this are poorly understood and little is known about the impact of specific anti-HIV drugs on neurological function. However, efavirenz – one of the most commonly used antiretrovirals […]

Can Efavirenz Dose Be Reduced?

The non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz (also known as Sustiva or Stocrin) is widely used as part of first-line therapy in the UK and many other countries, taken in combination with Truvada, or as part of the combined pill Atripla. Whilst very effective, it is known to have some significant side-effects in a relatively large minority of users. […]

Efavirenz and Pregnancy

Until now, it was advised that efavirenz, a widely-used anti-retroviral drug for the treatment of HIV, be avoided during pregnancy. New draft UK guidelines on the treatment of HIV in pregnancy no longer recommend that efavirenz (Sustiva, also part of the combination pill Atripla) should be avoided by pregnant women and women hoping to become pregnant. This means that women […]