Overall, HIV treatment reduces the risk of kidney disease. However, some anti-HIV drugs can affect kidney function and others can cause kidney stones. Atazanavir (taken with ritonavir as a “booster”) is a powerful anti-HIV drug in the class called protease inhibitors (PIs), and typically causes only mild side-effects. A new study suggests that treatment with ritonavir-boosted atazanavir is associated with amuch higher risk of kidney stones compared to other ritonavir-boosted protease inhibitors. There was also a high recurrence rate of kidney stones in people who continued to take atazanavir/ritonavir.
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