Adherence – taking your ARV drugs on time, every time – is a key part of HAART. Poor adherence can lead to drug resistance, and complicate future therapy. This article looks at different patterns of poor adherence, and finds that missing the occasional single dose is less harmful than taking an unplanned or unstructured “drug holiday” – not taking any ARVs for a prolonged period. This is perhaps not too surprising. Modern ARVs are generally more “forgiving” than older ARVs, so missing the odd dose infrequently is unlikely to be a serious problem; however, it is certainly best to aim for full adherence wherever possible.
The full article can be seen here.